A 27 year old woman, who had a previous history of one spontaneous abortion, was admitted to hospital: Clinical Haematology and Transfusion Science Case Study, UK

This is the case study: Case 1-1000 words

A 27 year old woman, who had a previous history of one spontaneous abortion, was admitted to hospital at 8 weeks of pregnancy suffering vaginal bleeding that resulted in the loss of her pregnancy. After her miscarriage, uterine malformations, hormonal abnormalities, chromosomal translocations, and infectious causes were excluded.

Three months after her miscarriage, she was tested for thrombophilic disorders. The following test results were returned: Protein S activity 45.4% (normal range 70-120%) Protein C activity 95.2% (normal range 70-140%) Activated Protein C 0.7R (normal range 0.86-1.1R) Resistance (APCR) Antithrombin III 95.9% (normal range 75-125%) Homocysteine 10.07 umol/L (normal range 5.0-14.0 umol/L) Anti-nuclear antibody Positive Lupus anticoagulant Negative Anticardiolipin Antibody IgM Factor V Leiden G1691A Heterozygous MTHFR C677T Heterozygous Prothrombin G20210A Negative Summarise these findings, their relevance in pregnancy and a possible therapeutic approach that would allow this woman to have a successful pregnancy.

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