Ms. TS is a 35–year–old female admitted to the hospital for fever, chills, and pain in her
side for 3 days. Dr. Hurt diagnoses bacterial peritonitis and wants to initiate vancomycin
therapy. Ms. TS’s height is 5’4″, admission weight 62 kg, and serum creatinine
1.4mg/dL. The vancomycin is to be infused over 1hour. Use expected pharmacokinetic
parameters based on average literature data and the patient’s clinical history to
calculate
1. Calculate a vancomycin clearance for this patient.
2. Calculate a vancomycin Volume of distribution for this patient.
3. Calculate a vancomycin half–life for this patient.
4. It was decided to start Ms. TS on vancomycin (infused over 1 hr.) to maintain a
trough concentration of 7.5 mg/L Calculate the initial vancomycin dose and
suggest an appropriate dosing regimen
5. What will be a once daily vancomycin dose for this patient?
6. Once a daily dose of 1500mg is administered Q24 hours, what would be the
predicted steady state vancomycin trough level for this patient?
