In 300-350 words, answer the following questions. Support with a minimum of one scholarly resource, ideally within the last 5 years. Journals and websites must be cited appropriately. Citations and references must adhere to APA format.
1) Discuss the role of mechanical stress, inflammation, and cartilage degradation in the progression of osteoarthritis. 2) How does aging contribute to the development of OA? What other risk factors (e.g., obesity, genetics, joint injury) play a significant role in the disease process? 3) Compare and contrast the normal physiology of articular cartilage with the pathologic changes that occur in osteoarthritis. 4) What are the systemic and local effects of inflammatory mediators (e.g., cytokines, matrix metalloproteinases) in the progression of osteoarthritis? 5) How do changes in the subchondral bone, synovium, and surrounding tissues contribute to the clinical manifestations of OA, such as pain, stiffness, and limited mobility?
